After neurology training, Dr. Loftus joined Diagnostic Clinic of Houston, a multispecialty physician group in the Texas Medical Center. He began doing Neurology Research at Diagnostic Clinic and has been Diagnostic Clinic's principal investigator on several studies. To date these studies have focused on migraines, diabetic neuropathy, post-herpetic neuralgia, and the prevention of stroke. Research funding has been provided by Astra-Zeneca, Glaxo, and Johnson and Johnson. In 2006, he left Diagnostic Clinic and started Bellaire Neurology.

Dr. Loftus has been an invited speaker for the Texas Association of Family Practice 2001 CME meeting and again in 2004. In 2003, he spoke for the Texas Neurological Association's Annual Meeting. He has presented MS research at international venues in 2005 and 2006. He is a member of the American Academy of Neurology, American Medical Association, Texas Neurological Association, Texas Medical Association, and the Harris County Medical Association.

Dr. Loftus believes strongly in the tradition of physicians educating their own. From medical students, to residents, to other specialists and contemporaries, Dr. Loftus loves to teach. For ten years, as Voluntary Associate Professor of Baylor College of Medicine, Department of Neurology, he spent part of each day one month (including weekends) each year as the Neurology Inpatient and Consult Attending at Ben Taub General Hospital. During this month, he was responsible for directing the neurology residents and medical students for all inpatient neurology patients. He current gives numerous educational talks each year to physicians on migraine, epilepsy, and neuropathic pain.

Dr. Loftus admits his private practice patients to either the Methodist Hospital, where he is on active staff or Park Plaza Hospital. He has served on a Quality Assurance Board of a medical hospital for 10 years.