Migraine is a very common disease which presently afflicts an estimated 21.9 million Americans. On the average, men experience 34 migraine attacks per year, while women experience 34.7 attacks per year. Slightly greater than half (58%) of these migraine attacks result in 112 million migraine-related bedridden ”sick-days” per year. It is estimated that the cost to the national economy is 1.03 billion dollars per year in direct health cost and 10.7 billion dollars per year indirect cost.

(Source) Burden of Migraine in the United States: Disability and Economic Costs, Henry X, Hu, M.D., MPH, PhD, et. Al., Archives of Internal Medicine, 159(8), 26 April 1999, 813-818